RT Journal Article
SR Electronic
T1 High Density of Tumor-infiltrating B-Lymphocytes and Plasma Cells Signifies Prolonged Overall Survival in Adenocarcinoma of the Esophagogastric Junction
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5339
OP 5345
VO 36
IS 10
A1 JULIANA KNIEF
A1 KATHARINA REDDEMANN
A1 EKATERINA PETROVA
A1 TOBIAS HERHAHN
A1 ULRICH WELLNER
A1 CHRISTOPH THORNS
YR 2016
UL http://ar.iiarjournals.org/content/36/10/5339.abstract
AB Background: Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic significance in a variety of tumors. Not only T-cell, but also B-cell infiltration is commonly associated with improved survival. Materials and Methods: We assessed the density of tumor-infiltrating B-cells, as well as that of plasma cells, in 210 adenocarcinomas of the esophagogastric junction through immunohistochemical analysis using antibodies against CD20 and CD138. Results: No correlation between density of B-cells or plasma cells and various clinicopathologic features could be established. High density of tumor-infiltrating B-cells, as well as plasma cells, showed significantly better overall survival (OS) compared to patients with no infiltrates (p=0.047 and p=0.022, respectively). Cox proportional hazard analysis could verify B-cell infiltration as an independent prognostic factor (hazard ratio (HR)=0.683; 95% confidence interval (CI)=0.517-0.901; p=0.007). Conclusion: Plasma cell and B-cell infiltration correlates with prolonged OS and might identify a patient subset with favorable disease course.