PT  - JOURNAL ARTICLE
AU  - JULIANA KNIEF
AU  - KATHARINA REDDEMANN
AU  - EKATERINA PETROVA
AU  - TOBIAS HERHAHN
AU  - ULRICH WELLNER
AU  - CHRISTOPH THORNS
TI  - High Density of Tumor-infiltrating B-Lymphocytes and Plasma Cells Signifies Prolonged Overall Survival in Adenocarcinoma of the Esophagogastric Junction
DP  - 2016 Oct 01
TA  - Anticancer Research
PG  - 5339--5345
VI  - 36
IP  - 10
4099  - http://ar.iiarjournals.org/content/36/10/5339.short
4100  - http://ar.iiarjournals.org/content/36/10/5339.full
SO  - Anticancer Res2016 Oct 01; 36
AB  - Background: Tumor-infiltrating lymphocytes (TILs) have been shown to be of prognostic significance in a variety of tumors. Not only T-cell, but also B-cell infiltration is commonly associated with improved survival. Materials and Methods: We assessed the density of tumor-infiltrating B-cells, as well as that of plasma cells, in 210 adenocarcinomas of the esophagogastric junction through immunohistochemical analysis using antibodies against CD20 and CD138. Results: No correlation between density of B-cells or plasma cells and various clinicopathologic features could be established. High density of tumor-infiltrating B-cells, as well as plasma cells, showed significantly better overall survival (OS) compared to patients with no infiltrates (p=0.047 and p=0.022, respectively). Cox proportional hazard analysis could verify B-cell infiltration as an independent prognostic factor (hazard ratio (HR)=0.683; 95% confidence interval (CI)=0.517-0.901; p=0.007). Conclusion: Plasma cell and B-cell infiltration correlates with prolonged OS and might identify a patient subset with favorable disease course.