TY - JOUR T1 - A Mouse Model of Fluorescent Protein-expressing Disseminated Peritoneal Lymphoma for Fluorescence-guided Surgery JF - Anticancer Research JO - Anticancer Res SP - 4483 LP - 4487 VL - 36 IS - 9 AU - TAKURO MATSUMOTO AU - ATSUSHI SUETSUGU AU - KOSUKE HASEGAWA AU - MIKI NAKAMURA AU - YUHEI SHIBATA AU - HITOMI AOKI AU - TAKAHIRO KUNISADA AU - HISASHI TSURUMI AU - MASAHITO SHIMIZU AU - MICHAEL BOUVET AU - ROBERT M. HOFFMAN Y1 - 2016/09/01 UR - http://ar.iiarjournals.org/content/36/9/4483.abstract N2 - Background: Fluorescence-guided surgery (FGS) of tumors is an area of intense development. Peritoneally-disseminated cancer, however, represents a difficult surgical challenge. Materials and Methods: To help meet this challenge, EL4 mouse T-cell lymphoma cells expressing red fluorescent protein (RFP) were injected intraperitoneally in nude mice. Results: Two weeks after injection of EL4-RFP cells, established peritoneally-disseminated tumors were observed. FGS was performed using a hand-held portable fluorescence imaging system (Dino-Lite). FGS enabled detection of very small peritoneal disseminated tumors and completely resected them in contrast to bright-light which only partially detected the tumors. Conclusion: The present report indicates the feasibility of FGS of peritoneally-disseminated cancer. ER -