TY - JOUR T1 - Parenchymal Congestion Is Important for Rapid Regeneration of the Future Liver Remnant Following the ALPPS Procedure JF - Anticancer Research JO - Anticancer Res SP - 4731 LP - 4738 VL - 36 IS - 9 AU - DAISUKE KAWAGUCHI AU - YUKIHIKO HIROSHIMA AU - KENICHI MATSUO AU - ITARU ENDO AU - KEIJI KODA AU - KUNIYA TANAKA Y1 - 2016/09/01 UR - http://ar.iiarjournals.org/content/36/9/4731.abstract N2 - Aim: To evaluate whether the congested area that develops in associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) contributes to rapid future liver remnant (FLR) hypertrophy. Patients and Methods: Eight patients undergoing liver partition and right portal vein (RPV) ligation within the FLR in the first operation of ALPPS were compared with eight patients undergoing RPV embolization in the FLR as the first operation of classical two-stage (CTS) hepatectomy. Results: Extrapolated kinetic growth of the FLR in ALPPS was 32.7±18.7 ml/day, 7.8-times that in CTS (4.2±2.0 ml/day, p=0.001). Extrapolated kinetic reduction in volume of the ventral aspect of the right paramedian sector, which became congested after the first procedure in ALPPS, was 19.8±11.6 ml/day, 11-times that in CTS (1.8±1.3 ml/day, p=0.001). Conclusion: Production of a congested area within the deportalized liver may contribute importantly to rapid FLR hypertrophy during ALPPS. ER -