TY - JOUR T1 - Minodronic Acid in Combination with γδT Cells Induces Apoptosis of Non-small Cell Lung Carcinoma Cell Lines JF - Anticancer Research JO - Anticancer Res SP - 5883 LP - 5886 VL - 36 IS - 11 AU - MOTOAKI YASUKAWA AU - TSUTOMU NAKAZAWA AU - TAKESHI KAWAGUCHI AU - NORIKAZU KAWAI AU - TAKAHIRO TSUJIMURA AU - TAKASHI TOJO AU - SHIGEKI TANIGUCHI Y1 - 2016/11/01 UR - http://ar.iiarjournals.org/content/36/11/5883.abstract N2 - Background/Aim: Non-small cell lung carcinoma (NSCLC) is one of the leading causes of cancer-related death worldwide. Recent studies showed that nitrogen-containing bisphosphonates (N-BPs) directly and indirectly prevent proliferation, induce apoptosis, and inhibit metastasis of various types of cancer cell. In order to investigate the effect of combining minodronic acid (MDA) with γδ T-cells, NSCLC cells were treated with five concentrations of MDA. Materials and Methods: NSCLC cells were cultured with different concentrations of MDA alone or in combination with γδ T-cells for 24 h. Results: MDA with γδ T-cells had differential apoptotic effects on the NSCLC cell lines. The cells showed significant apoptotic effects in the presence of MDA in a dose-dependent manner. Conclusion: This study is the first to report an indirect effect of MDA against NSCLC. We report the induction of apoptosis by MDA in combination with γδ T-cells. ER -