@article {YASUKAWA5883, author = {MOTOAKI YASUKAWA and TSUTOMU NAKAZAWA and TAKESHI KAWAGUCHI and NORIKAZU KAWAI and TAKAHIRO TSUJIMURA and TAKASHI TOJO and SHIGEKI TANIGUCHI}, title = {Minodronic Acid in Combination with γδT Cells Induces Apoptosis of Non-small Cell Lung Carcinoma Cell Lines}, volume = {36}, number = {11}, pages = {5883--5886}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Non-small cell lung carcinoma (NSCLC) is one of the leading causes of cancer-related death worldwide. Recent studies showed that nitrogen-containing bisphosphonates (N-BPs) directly and indirectly prevent proliferation, induce apoptosis, and inhibit metastasis of various types of cancer cell. In order to investigate the effect of combining minodronic acid (MDA) with γδ T-cells, NSCLC cells were treated with five concentrations of MDA. Materials and Methods: NSCLC cells were cultured with different concentrations of MDA alone or in combination with γδ T-cells for 24 h. Results: MDA with γδ T-cells had differential apoptotic effects on the NSCLC cell lines. The cells showed significant apoptotic effects in the presence of MDA in a dose-dependent manner. Conclusion: This study is the first to report an indirect effect of MDA against NSCLC. We report the induction of apoptosis by MDA in combination with γδ T-cells.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/11/5883}, eprint = {https://ar.iiarjournals.org/content/36/11/5883.full.pdf}, journal = {Anticancer Research} }