RT Journal Article
SR Electronic
T1 Discovery of Anticancer Agents of Diverse Natural Origin
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5623
OP 5637
VO 36
IS 11
A1 A. DOUGLAS KINGHORN
A1 ESPERANZA J. CARCACHE DE BLANCO
A1 DAVID M. LUCAS
A1 H. LIVA RAKOTONDRAIBE
A1 JIMMY ORJALA
A1 D. DOEL SOEJARTO
A1 NICHOLAS H. OBERLIES
A1 CEDRIC J. PEARCE
A1 MANSUKH C. WANI
A1 BRENT R. STOCKWELL
A1 JOANNA E. BURDETTE
A1 STEVEN M. SWANSON
A1 JAMES R. FUCHS
A1 MITCHELL A. PHELPS
A1 LIHUI XU
A1 XIAOLI ZHANG
A1 YOUNG YONGCHUN SHEN
YR 2016
UL http://ar.iiarjournals.org/content/36/11/5623.abstract
AB Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.