@article {FUJII4337, author = {TAKAAKI FUJII and REINA YAJIMA and HIROYUKI KUWANO}, title = {Implications of Long-term Indwelling of Tissue Expander in Breast Reconstruction: Risk of Expander Rupturing}, volume = {36}, number = {8}, pages = {4337--4340}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Breast reconstruction with a tissue expander (TE) is associated with postoperative complications, including rupturing of the TE. Any device can have a mechanical failure, and a TE may rupture over time. Although an interval of around one year from initial TE insertion to the second stage of two-stage surgery is historically considered the standard, the optimal interval has not yet been determined. Furthermore, the durability of a TE and the influence of long-term indwelling on TE rupture are uncertain. In this study, we retrospectively investigated the effects of long-term indwelling on TE durability and rupturability. Patients and Methods: We analyzed 24 patients and 25 breasts with breast cancer that had undergone breast reconstruction with an expander that was indwelling for more than a year. The resected margins were all clear, and none of the patients required postoperative radiotherapy. Results: From a total of 25 reconstructed breast mounds, the TE ruptured in 4 cases. None of the clinicopathological features, including primary tumor progression, method of operation, presence of adjuvant chemotherapy, was significantly associated with TE rupture. Rupture was observed beginning at 1.5 years after the initial TE insertion. The rupture rate was 32.6\% by the third year and 55.1\% by five years. There were no ruptures among cases with TE exchange within a year. Conclusion: Long-term indwelling of TE is associated with TE rupture. We recommend that the appropriate interval between the first and second stages of breast reconstructive surgery is aproximatelly one year.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/8/4337}, eprint = {https://ar.iiarjournals.org/content/36/8/4337.full.pdf}, journal = {Anticancer Research} }