@article {HOWARD3933, author = {CAROLYN B. HOWARD and RODERICK MCDOWELL and KIDUS FELEKE and EVANGELINE DEER and SYMONE STAMPS and EASTER THAMES and VIKASH SINGH and SHEHLA PERVIN}, title = {Chemotherapeutic Vulnerability of Triple-negative Breast Cancer Cell-derived Tumors to Pretreatment with Vernonia amygdalina Aqueous Extracts}, volume = {36}, number = {8}, pages = {3933--3943}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Unresponsive to most clinical therapies, triple-negative breast cancer (TNBC) is the dominant biological cause of population-based racioethnic disparities in breast cancer mortality in the United States. We report the chemotherapeutic vulnerability of TNBC cells and stem cell-derived tumors to Vernonia amygdalina aqueous leaf extracts (VA extracts). VA extracts arrest cell proliferation and induce apoptosis in vitro and inhibit growth of implanted tumors and show chemo-preventive efficacy in vivo. Materials and Methods: HRAS cells and MDA-MB-468 cells were subcutaneously implanted into nude mice with or without pretreatment with VA extracts before chemotherapeutic treatment with VA extracts and/or paclitaxel to evaluate their ability to inhibit tumor growth. Results: The most significant reduction in tumor volume was observed in the MDA-MB-468 cell-induced tumors following VA extract pre-treatment compared to those from HRAS cell implantation. Conclusion: VA extracts induce apoptosis, exhibit additive effects, inhibit tumor growth and display chemo-preventive actions against TNBCs.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/8/3933}, eprint = {https://ar.iiarjournals.org/content/36/8/3933.full.pdf}, journal = {Anticancer Research} }