TY - JOUR T1 - Primary and Secondary Soft Tissue Angiosarcomas: Prognostic Significance of Surgical Margins in 43 Patients JF - Anticancer Research JO - Anticancer Res SP - 4321 LP - 4328 VL - 36 IS - 8 AU - KAMRAN HARATI AU - ADRIEN DAIGELER AU - OLE GOERTZ AU - JENS BÖHM AU - KIM LANGE AU - INGO STRICKER AU - JONAS KOLBENSCHLAG AU - MARCUS LEHNHARDT Y1 - 2016/08/01 UR - http://ar.iiarjournals.org/content/36/8/4321.abstract N2 - Background: Angiosarcomas are aggressive soft tissue sarcomas. Due to their rarity there is a paucity of data regarding the clinical outcome of patients with non-visceral angiosarcomas of the soft tissues. In particular, the prognostic significance of surgical margins remains controversial. Patients and Methods: We retrospectively assessed the outcome of 43 patients with localised disease suitable for surgical treatment with curative intent. The median follow-up was 7.5 years. Results: The 5-year overall survival (OS) rate was 46.2%. Sixteen patients (37.2%) were diagnosed with secondary, radiation-induced angiosarcomas. Twenty-four patients (55.8%) developed local recurrences and 15 patients (34.9%) distant metastases. Negative surgical margin emerged as the only statistically significant prognostic factor (5-year OS: R0 51.8% vs. R1/R2 17.1%, p=0.036). As indicated in the regression analysis, close and wide negative margins within the R0 subgroup led to similar outcomes. Conclusion: Angiosarcomas have a high risk of local recurrence and metastasis. Surgical resection with negative margins improves the outcome. ER -