@article {HARATI4321, author = {KAMRAN HARATI and ADRIEN DAIGELER and OLE GOERTZ and JENS B{\"O}HM and KIM LANGE and INGO STRICKER and JONAS KOLBENSCHLAG and MARCUS LEHNHARDT}, title = {Primary and Secondary Soft Tissue Angiosarcomas: Prognostic Significance of Surgical Margins in 43 Patients}, volume = {36}, number = {8}, pages = {4321--4328}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Angiosarcomas are aggressive soft tissue sarcomas. Due to their rarity there is a paucity of data regarding the clinical outcome of patients with non-visceral angiosarcomas of the soft tissues. In particular, the prognostic significance of surgical margins remains controversial. Patients and Methods: We retrospectively assessed the outcome of 43 patients with localised disease suitable for surgical treatment with curative intent. The median follow-up was 7.5 years. Results: The 5-year overall survival (OS) rate was 46.2\%. Sixteen patients (37.2\%) were diagnosed with secondary, radiation-induced angiosarcomas. Twenty-four patients (55.8\%) developed local recurrences and 15 patients (34.9\%) distant metastases. Negative surgical margin emerged as the only statistically significant prognostic factor (5-year OS: R0 51.8\% vs. R1/R2 17.1\%, p=0.036). As indicated in the regression analysis, close and wide negative margins within the R0 subgroup led to similar outcomes. Conclusion: Angiosarcomas have a high risk of local recurrence and metastasis. Surgical resection with negative margins improves the outcome.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/8/4321}, eprint = {https://ar.iiarjournals.org/content/36/8/4321.full.pdf}, journal = {Anticancer Research} }