RT Journal Article SR Electronic T1 The Tumor Suppressor MicroRNA-1 Exhibits Restricted Inhibition of Proliferation of Ovarian Cancer Cells JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 3329 OP 3334 VO 36 IS 7 A1 MATTHIAS B. STOPE A1 DARIA HETTENBACH A1 ANNE KAUL A1 MADELEINE PADITZ A1 KAROLINE DIESING A1 MARTIN BURCHARDT A1 MAREK ZYGMUNT A1 ALEXANDER MUSTEA A1 DOMINIQUE KOENSGEN YR 2016 UL http://ar.iiarjournals.org/content/36/7/3329.abstract AB Background: MicroRNAs are able to control vital tumor biological processes, such as proliferation, tissue transformation and cell migration, as well as apoptosis. One of the micro RNAs, namely miR-1, has been classified as a tumor suppressor, however, preliminary data did not confirm this finding in ovarian cancer (OC) cells. This study examined the impact of miR-1 on OC cell growth. Materials and Methods: Recombinant miR-1 was overexpressed in human OC cell lines OVCAR-3, SK-OV-3, TOV-112D, and TOV-21G. Subsequently, cell growth was analyzed. Results: After transfection, 11- to 487-fold overexpression of miR-1 was detectable in the OC cells. However, no significant differences in proliferation compared to control cells were detected, neither in transiently nor in stably transfected cells. Conclusion: In numerous cancer entities miR-1 is defined as an antiproliferative tumor suppressor. Notably, the present study demonstrated a loss of growth-inhibitory functionality of miR-1 by so far unknown mechanisms, suggesting dysregulated miR-1 signaling or effector cascades in OC cells.