RT Journal Article SR Electronic T1 Sentinel Lymph Node Detection by Blue Dye Versus Indocyanine Green Fluorescence Imaging in Colon Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4853 OP 4858 VO 36 IS 9 A1 LIBERALE, GABRIEL A1 VANKERCKHOVE, SOPHIE A1 GALDON, MARIA GOMEZ A1 LARSIMONT, DENIS A1 AHMED, BISSAN A1 BOUAZZA, FIKRI A1 MOREAU, MICHEL A1 EL NAKADI, ISSAM A1 DONCKIER, VINCENT A1 BOURGEOIS, PIERRE A1 R&D Group for the Clinical Application of Fluorescence Imaging at the Jules Bordet Institute YR 2016 UL http://ar.iiarjournals.org/content/36/9/4853.abstract AB Background/Aim: Nodal staging is used in colorectal cancer (CRC) to determine which patients should receive adjuvant chemotherapy. The aim of this study was to evaluate the role of indocyanine green fluorescence imaging (ICG-FI) in sentinel lymph node (SLN) detection compared to the standard technique. Materials and Methods: Twenty patients with CRC admitted for elective colectomy were included (NCT01995591). Ex vivo SLN detection was performed using patent blue (PB) and free ICG injected around the tumor. Results: Identification rates were 95% (19/20) for both techniques. Sensitivity was 43% for PB and 57% for ICG. Correlation between the techniques was 83%. FI was more sensitive in patients with body mass index (BMI) >25 kg/m2. Serial section analysis did not allow for up-staging of patients. Conclusion: The use of ICG-FI is superior to the blue dye technique in patients with a BMI >25 kg/m2. However, the sensitivity of ICG-FI in SLN detection remains low, with a high rate of false-negative results.