TY - JOUR T1 - Synchronous Quadruple Primary Neoplasms: Colon Adenocarcinoma, Collision Tumor of Neuroendocrine Tumor and Schwann Cell Hamartoma and Sessile Serrated Adenoma of the Appendix JF - Anticancer Research JO - Anticancer Res SP - 4307 LP - 4311 VL - 36 IS - 8 AU - MARSHALL W. MEEKS AU - SHANE GRACE AU - YONGXIN CHEN AU - JAMES PETTERCHAK AU - EDWARD BOLESTA AU - YIHUA ZHOU AU - JIN-PING LAI Y1 - 2016/08/01 UR - http://ar.iiarjournals.org/content/36/8/4307.abstract N2 - Quadruple synchronous primary neoplasms are very rare with only three cases reported in the English-speaking literature to date. Collision tumors are also rare entities, especially of the appendix. We herein report a case of synchronous quadruple primary neoplasm in a 95-year-old female. She was diagnosed with colon adenocarcinoma, sessile serrated adenoma of the appendix and a collision tumor composed of a well-differentiated neuroendocrine tumor and Schwann cell hamartoma. Histological examination and immunohistochemistry supported these four lesions as separate entities. This case is unique because we report the diagnosis of quadruple synchronous primary, an extremely rare occurrence, in addition to a collision tumor of the appendix. We also provide a review of the literature for synchronous neoplasms and collision tumors. ER -