@article {MIYAHARA3725, author = {DAISUKE MIYAHARA and TAKAHIRO KATSUTA and MIYAKO MAEHARA and YOKO TAKAHASHI and SATOSHI FUKAGAWA and KOUHEI MIYATA and CHIHIRO KIYOSHIMA and FUSANORI YOTSUMOTO and HARUCHIKA ANAN and SHINGO MIYAMOTO}, title = {Safety and Anti-tumor Effects of Docetaxel Plus Cisplatin in Intermediate- and High-risk Endometrial Cancer}, volume = {36}, number = {7}, pages = {3725--3729}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Endometrial cancer (EC) has a poor prognosis due to drug resistance. Patients and Methods: We evaluated the safety and efficacy of adjuvant combination chemotherapy with docetaxel plus cisplatin ((DP) docetaxel, 70 mg/m2; cisplatin, 60 mg/m2; every 28 days) in EC patients at intermediate-risk (IR) or high-risk (HR) for recurrence. Results: Sixty-four patients diagnosed with EC were enrolled. Stage-I, -II, -III and -IV disease was noted in 23, 7, 28 and 6 patients, respectively. Histopathological analyses revealed that 56, 3, 1 and 4 patients had endometrioid, serous, clear-cell or {\textquotedblleft}other{\textquotedblright} types of carcinoma. Grade-3/4 hematologic toxicities were found at 80\% and 95\% in patients in IR and HR groups, respectively. In IR and HR groups, mean progression-free (PFS) survival was 69.5 and 29.5, while overall survival (OS) was 59.6 and 47.5 months, respectively. Conclusion: DP may be clinically safe and useful treatment for EC.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/7/3725}, eprint = {https://ar.iiarjournals.org/content/36/7/3725.full.pdf}, journal = {Anticancer Research} }