TY - JOUR T1 - Screening for Identification of Personalized Food to Promote Adiponectin Secretion in Patients with Cancer JF - Anticancer Research JO - Anticancer Res SP - 3673 LP - 3677 VL - 36 IS - 7 AU - MIKI SAKAUE AU - KAZUHISA MAEDA AU - SATOSHI OHNO AU - TOSHINORI ITO Y1 - 2016/07/01 UR - http://ar.iiarjournals.org/content/36/7/3673.abstract N2 - Background/Aim: Adiponectin is secreted specifically from adipose tissue. Low serum adiponectin levels may cause metabolic syndrome, which is also a risk factor for carcinogenesis. Several studies have suggested a negative correlation between adiponectin and risk of cancers. This study examined the adiponectin secretion-promoting effect of food ingredients in adipose-derived stem cells (ADSCs) obtained from patients with cancer. Patients and Methods: ADSCs from 7 lifestyle disease cancer patients were differentiated into adipocytes. Subsequently, the adipocytes were treated with 49 food constituents. The adiponectin levels in cell culture supernatants were measured after 48 and 96 h. Results: Soy genistein extract, lychee low-molecular-weight polyphenol, olive extract and turmeric promoted adiponectin secretion. Conclusion: Food constituents that promoted adiponectin secretion were identified using ADSCs derived from patients. This study suggested the possibility of a new treatment approach to prevent cancer recurrence. ER -