%0 Journal Article %A DONGSHENG YANG %A YUHUAN LI %A YUHANG QI %A YONGZHEN CHEN %A XUEWEI YANG %A YUJING LI %A SONGCAI LIU %A ROBERT J. LEE %T Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine %D 2016 %J Anticancer Research %P 3271-3276 %V 36 %N 7 %X Cationic liposomes incorporating stearic acid-modified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself. %U https://ar.iiarjournals.org/content/anticanres/36/7/3271.full.pdf