TY - JOUR T1 - Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine JF - Anticancer Research JO - Anticancer Res SP - 3271 LP - 3276 VL - 36 IS - 7 AU - DONGSHENG YANG AU - YUHUAN LI AU - YUHANG QI AU - YONGZHEN CHEN AU - XUEWEI YANG AU - YUJING LI AU - SONGCAI LIU AU - ROBERT J. LEE Y1 - 2016/07/01 UR - http://ar.iiarjournals.org/content/36/7/3271.abstract N2 - Cationic liposomes incorporating stearic acid-modified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself. ER -