RT Journal Article
SR Electronic
T1 Nuclear Y-Box-binding Protein-1 Expression Predicts Poor Clinical Outcome in Stage III Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3781
OP 3788
VO 36
IS 7
A1 SACHIKO SHIRAIWA
A1 TETSUSHI KINUGASA
A1 AKIHIKO KAWAHARA
A1 TOMOAKI MIZOBE
A1 TAKAFUMI OHCHI
A1 KOTARO YUGE
A1 SHINYA FUJINO
A1 MITSUHIRO KATAGIRI
A1 SUSUMU SHIMOMURA
A1 KENSUKE TAJIRI
A1 TOMOYA SUDO
A1 MASAYOSHI KAGE
A1 MICHIHIKO KUWANO
A1 YOSHITO AKAGI
YR 2016
UL http://ar.iiarjournals.org/content/36/7/3781.abstract
AB Background/aim: Y-Box-binding protein-1 (YB-1), a DNA/RNA-binding protein, is an important oncogenic transcription and translation factor. We aimed to evaluate the relationships between nuclear YB-1 expression, epidermal growth factor receptor (EGFR) status, and poor clinical outcomes in patients with colorectal cancer (CRC). Materials and Methods: Nuclear YB-1 expression was immunohistochemically analyzed in CRC tissues obtained from 124 patients who underwent curative resection between 2005 and 2008. Correlations between nuclear YB-1 expression, various clinicopathological characteristics, EGFR status, and prognostic factors were evaluated. Results: High-grade nuclear YB-1 expression was detected in 62.9% of cases and was found to be an independent predictor of poorer overall survival (p<0.001) and relapse-free survival (p<0.001). A trend was also observed towards a positive correlation between nuclear YB-1 expression and EGFR status (p=0.051). Conclusion: Nuclear YB-1 expression is a useful prognostic biomarker that correlates with EGFR status in patients with CRC.