RT Journal Article
SR Electronic
T1 Hepatic Arterial Infusion of Polyethylene Glycol Drug-eluting Beads for Primary and Metastatic Liver Cancer Therapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3515
OP 3521
VO 36
IS 7
A1 CAMILLO ALIBERTI
A1 RICCARDO CARANDINA
A1 DONATELLA SARTI
A1 LUCA MULAZZANI
A1 VINCENZO CATALANO
A1 ALESSANDRO FELICIOLI
A1 PAOLO COSCHIERA
A1 GIAMMARIA FIORENTINI
YR 2016
UL http://ar.iiarjournals.org/content/36/7/3515.abstract
AB Background/Aim: Recently, there has been the launch of the new Polyethylene glycol (PEG) drug-eluting beads (LifePearl®) for transarterial chemoembolization. Their innovation is that PEG guarantees more compressibility, elasticity and maximizes beads' suspension time. We applied these beads for hepatic intra-arterial infusion of irinotecan or doxorubicin for the therapy of primary and metastatic liver cancer. Patients and Methods: We treated 20 consecutive patients, affected by unresectable primary liver cancer (PLC) or hepatic metastases (refractory to chemotherapy) using chemoembolization with doxorubicin or irinotecan pre-loaded Lifepearls. Results: Tumor response rate was >80% in most patients with 63% of complete and 37% of partial response. We observed no complications during the chemoembolization and no severe general drug-related side-effects. Conclusion: Our data suggest that chemoembolization with LifePearl® is efficacious and safe for the treatment of liver cancer as indicated by good tolerability, quality of life and high tumor response.