TY - JOUR T1 - Hepatic Arterial Infusion of Polyethylene Glycol Drug-eluting Beads for Primary and Metastatic Liver Cancer Therapy JF - Anticancer Research JO - Anticancer Res SP - 3515 LP - 3521 VL - 36 IS - 7 AU - CAMILLO ALIBERTI AU - RICCARDO CARANDINA AU - DONATELLA SARTI AU - LUCA MULAZZANI AU - VINCENZO CATALANO AU - ALESSANDRO FELICIOLI AU - PAOLO COSCHIERA AU - GIAMMARIA FIORENTINI Y1 - 2016/07/01 UR - http://ar.iiarjournals.org/content/36/7/3515.abstract N2 - Background/Aim: Recently, there has been the launch of the new Polyethylene glycol (PEG) drug-eluting beads (LifePearlĀ®) for transarterial chemoembolization. Their innovation is that PEG guarantees more compressibility, elasticity and maximizes beads' suspension time. We applied these beads for hepatic intra-arterial infusion of irinotecan or doxorubicin for the therapy of primary and metastatic liver cancer. Patients and Methods: We treated 20 consecutive patients, affected by unresectable primary liver cancer (PLC) or hepatic metastases (refractory to chemotherapy) using chemoembolization with doxorubicin or irinotecan pre-loaded Lifepearls. Results: Tumor response rate was >80% in most patients with 63% of complete and 37% of partial response. We observed no complications during the chemoembolization and no severe general drug-related side-effects. Conclusion: Our data suggest that chemoembolization with LifePearlĀ® is efficacious and safe for the treatment of liver cancer as indicated by good tolerability, quality of life and high tumor response. ER -