@article {ALIBERTI3515, author = {CAMILLO ALIBERTI and RICCARDO CARANDINA and DONATELLA SARTI and LUCA MULAZZANI and VINCENZO CATALANO and ALESSANDRO FELICIOLI and PAOLO COSCHIERA and GIAMMARIA FIORENTINI}, title = {Hepatic Arterial Infusion of Polyethylene Glycol Drug-eluting Beads for Primary and Metastatic Liver Cancer Therapy}, volume = {36}, number = {7}, pages = {3515--3521}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Recently, there has been the launch of the new Polyethylene glycol (PEG) drug-eluting beads (LifePearl{\textregistered}) for transarterial chemoembolization. Their innovation is that PEG guarantees more compressibility, elasticity and maximizes beads{\textquoteright} suspension time. We applied these beads for hepatic intra-arterial infusion of irinotecan or doxorubicin for the therapy of primary and metastatic liver cancer. Patients and Methods: We treated 20 consecutive patients, affected by unresectable primary liver cancer (PLC) or hepatic metastases (refractory to chemotherapy) using chemoembolization with doxorubicin or irinotecan pre-loaded Lifepearls. Results: Tumor response rate was \>80\% in most patients with 63\% of complete and 37\% of partial response. We observed no complications during the chemoembolization and no severe general drug-related side-effects. Conclusion: Our data suggest that chemoembolization with LifePearl{\textregistered} is efficacious and safe for the treatment of liver cancer as indicated by good tolerability, quality of life and high tumor response.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/7/3515}, eprint = {https://ar.iiarjournals.org/content/36/7/3515.full.pdf}, journal = {Anticancer Research} }