PT  - JOURNAL ARTICLE
AU  - CHEN-HSIEN SU
AU  - HSIEN-YUAN LANE
AU  - CHIEH-LUN HSIAO
AU  - LIANG-CHIH LIU
AU  - HONG-XUE JI
AU  - HSIN-TING LI
AU  - SHIOU-TING YEN
AU  - CHUNG-HAO SU
AU  - TE-CHUN HSIA
AU  - WEN-SHIN CHANG
AU  - CHIA-WEN TSAI
AU  - DA-TIAN BAU
TI  - Matrix Metalloproteinase-1 Genetic Polymorphism in Breast Cancer in Taiwanese
DP  - 2016 Jul 01
TA  - Anticancer Research
PG  - 3341--3345
VI  - 36
IP  - 7
4099  - http://ar.iiarjournals.org/content/36/7/3341.short
4100  - http://ar.iiarjournals.org/content/36/7/3341.full
SO  - Anticancer Res2016 Jul 01; 36
AB  - Aim: Metalloproteinases (MMPs) are a family of enzymes involved in many physiological processes, such as skeletal development, wound healing, and scar formation, as well as carcinogenesis. However, the contribution of MMP1 genotype to breast cancer has not been elucidated. This study aimed to evaluate the contribution of commonly studied MMP1 promoter 1607 genotype to breast cancer risk. Materials and Methods: In this hospital-based case–control study, contribution of MMP1 genotype to breast cancer risk was evaluated among 1,232 patients with breast cancer and 1,232 gender-matched healthy controls. Results: The distribution of 2G/2G, 1G/2G and 1G/1G for MMP1 promoter 1607 genotype was 36.0%, 41.3% and 22.7% in the breast cancer group and 34.2%, 44.5% and 21.3% in the non-cancer group, respectively (p for trend=0.2820). We also analyzed the allelic frequency distributions and found that the variant 1G allele of MMP1 promoter 1607 conferred similar breast cancer susceptibility as the wild-type 2G allele (odds ratio=0.99, 95% confidence interval=0.89-1.11, p=0.8858). There was no interaction between MMP1 promoter 1607 genotype and cigarette smoking or alcohol drinking habits. Conclusion: The genotype of MMP1 promoter 1607 may not be a major determining factor for breast cancer risk. The contribution of MMP1 promoter 1607 genotype to prognosis and subtypes of breast cancer needs further investigation.