RT Journal Article
SR Electronic
T1 Initial Results of Hypofractionated Carbon Ion Radiotherapy for Cholangiocarcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2955
OP 2960
VO 36
IS 6
A1 ABE, TAKANORI
A1 SHIBUYA, KEI
A1 KOYAMA, YOSHINORI
A1 OKAMOTO, MASAHIKO
A1 KIYOHARA, HIROKI
A1 KATOH, HIROYUKI
A1 SHIMADA, HIROHUMI
A1 KUWANO, HIROYUKI
A1 OHNO, TATSUYA
A1 NAKANO, TAKASHI
YR 2016
UL http://ar.iiarjournals.org/content/36/6/2955.abstract
AB Aim: To report initial results of hypofractionated carbon ion radiotherapy (C-ion RT) for cholangiocarcinoma. Patients and Methods: Data regarding seven patients with cholangiocarcinoma treated by C-ion RT were analyzed. Prescribed doses were 52.8 Gy [relative biological effectiveness (RBE)] or 60.0 Gy (RBE) in four fractions for intrahepatic cases and 12 fractions for hilar hepatic/close to gastro-intestinal tract cases. Local control and overall survival were evaluated and toxicity was graded using Common Terminology Criteria for Adverse Events, version 4.0. Results: The median follow-up period was 16 months. There were two patients with stage I cancer, one with stage II, one with stage III, and three with stage IVA. Local control was achieved in five out of seven patients (71%) and survival was maintained in six out of seven patients (86%). There were no occurrences of acute or late toxicity of grade 3 or higher. Conclusion: Initial results show that hypofractionated C-ion RT appears to be tolerated and effective for cholangiocarcinoma.