RT Journal Article
SR Electronic
T1 Clinicopathological Correlations of Autophagy-related Proteins LC3, Beclin 1 and p62 in Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 129
OP 136
VO 36
IS 1
A1 GO MASUDA
A1 MASAKAZU YASHIRO
A1 KISHU KITAYAMA
A1 YUICHIRO MIKI
A1 HIROAKI KASASHIMA
A1 HARUHITO KINOSHITA
A1 TAMAMI MORISAKI
A1 TATSHUNARI FUKUOKA
A1 TSUYOSHI HASEGAWA
A1 KATSUNOBU SAKURAI
A1 TAKAHIRO TOYOKAWA
A1 NAOSHI KUBO
A1 HIROAKI TANAKA
A1 KAZUYA MUGURUMA
A1 OHIRA MASAICHI
A1 KOSEI HIRAKAWA
YR 2016
UL http://ar.iiarjournals.org/content/36/1/129.abstract
AB Aim: This study evaluated the clinicopathological significance of autophagy, an intracellular degradation system, in gastric cancer. Materials and Methods: The expression levels of three autophagy-related proteins, namely light chain 3 (LC3), Beclin 1 and p62, were analyzed by immunohistochemistry using samples from 510 patients with primary gastric cancer. Results: LC3, Beclin 1, and p62 expression was positive in 79 (15.5%), 126 (24.7%) and 251 (49.2%) out of 510 carcinomas, respectively. Autophagy was defined when samples were positive for at least two out of the three proteins. Autophagy-positive cases were 113 (22.1%) out of the 510. Autophagy determined by LC3, Beclin 1, and p62 significantly correlated with lymph node metastasis, vessel invasion, and hepatic metastasis. A Kaplan–Meier survival curve showed that autophagy was significantly associated with poor survival of patients with gastric cancer, especially for those with disease at stage I. Multivariate analysis indicated that autophagy was an independent prognostic factor. Conclusion: Autophagy promotes the progression of gastric cancer at an early clinical stage.