@article {GITT355, author = {ALEXANDER GITT and HUGO B{\"O}SE-RIBEIRO and CARSTEN NIEDER and PHILIPP G{\"U}NTHER KUP and HORST HERMANI and HELMUT B{\"U}HLER and HASAN YAVUZ ERG{\"O}NEN{\c C} and DOROTHEE DR{\"U}PPEL and IREN{\"A}US ANTON ADAMIETZ and KHASHAYAR FAKHRIAN}, title = {Treatment Results of MammoSite Catheter in Combination with Whole-breast Irradiation}, volume = {36}, number = {1}, pages = {355--360}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Aim. To report the initial outcomes of patients treated with the MammoSite brachytherapy device (MSBT) as a boost followed by external whole-breast irradiation (WBI). Patients and Methods: From June 2011 to March 2014, 107 patients (typically with pT1-2, pN0-1, M0 disease) were treated with breast-conserving therapy and adjuvant radiotherapy with MSBT (15 Gy in 2.5-Gy fractions) followed by WBI (median=50.4 Gy). Toxicity was classified according to the Common Terminology Criteria for Adverse Events v3.0. The median follow-up was 21 months. Results: To date, no ipsilateral breast-tumor recurrences have been observed; 102 patients (95\%) were alive at last follow-up. Two patients (2\%) developed distant metastases. Five patients (5\%) died during follow-up, only one as a result of breast cancer. The 2-year disease-free survival was 95{\textpm}3\%. The incidence of asymptomatic and symptomatic seroma in 90 days after MSBT was 28\% and 10\%, respectively. Infectious mastitis was observed in three patients (3\%), who were treated successfully with antibiotics. Only three patients (3\%) developed RT-induced dermatitis greater than grade 2 after WBI. Conclusion: The boost technique used in this study seems to provide excellent local control with acceptable toxicity, similar to the results observed with other forms of interstitial accelerated partial-breast irradiation as a boost. Long-term follow-up is necessary to refine the patient selection criteria and to assess efficacy and late toxicities.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/1/355}, eprint = {https://ar.iiarjournals.org/content/36/1/355.full.pdf}, journal = {Anticancer Research} }