TY - JOUR T1 - Prognostic Significance of Serum and Urinary Neopterin Concentrations in Patients with Rectal Carcinoma Treated with Chemoradiation JF - Anticancer Research JO - Anticancer Res SP - 287 LP - 292 VL - 36 IS - 1 AU - MICHAELA ZEZULOVÁ AU - MARIE BARTOUŠKOVÁ AU - EVA HLÍDKOVÁ AU - JARMILA JURÁŇOVÁ AU - BARBORA ČERVINKOVÁ AU - EVA KASALOVÁ AU - TOMÁŠ ADAM AU - LENKA KUJOVSKÁ KRČMOVÁ AU - DAGMAR SOLICHOVÁ AU - KAREL CWIERTKA AU - DAVID VRÁNA AU - BOHUSLAV MELICHAR Y1 - 2016/01/01 UR - http://ar.iiarjournals.org/content/36/1/287.abstract N2 - Aim: To analyze the prognostic significance of serum and urinary neopterin concentrations in patients with rectal adenocarcinoma treated with (chemo)radiation. Patients and Methods: Urinary and serum neopterin and peripheral blood cell count were determined in 49 patients with rectal carcinoma before the start of (chemo)radiation. Results: Neopterin concentrations exhibited a significant inverse correlation with hemoglobin and positive correlation with leukocyte count, platelet count and platelet-to-lymphocyte ratio. Increased serum neopterin concentration was associated with significantly inferior relapse-free survival (RFS) and overall survival. However, a significant association was observed only in 28 patients treated in the neoadjuvant setting. Although increased urinary neopterin was also associated with inferior RFS and overall survival, this was not statistically significant. The neutrophil-to-lymphocyte ratio was also associated with poor prognosis. Conclusion: The data presented herein indicate a prognostic significance of serum neopterin concentrations in patients with rectal cancer treated with neoadjuvant chemoradiation. ER -