TY - JOUR T1 - Gremlin 2 is Repressed in Invasive Endometrial Cancer and Inhibits Cell Growth <em>In Vitro</em> JF - Anticancer Research JO - Anticancer Res SP - 199 LP - 203 VL - 36 IS - 1 AU - HIROSHI TSUBAMOTO AU - KAZUKO SAKATA AU - RIYA SAKANE AU - KAYO INOUE AU - HIROAKI SHIBAHARA AU - HIROYUKI HAO AU - SEIICHI HIROTA Y1 - 2016/01/01 UR - http://ar.iiarjournals.org/content/36/1/199.abstract N2 - Background: There exist limited therapeutic opportunities regarding the treatment of endometrial cancer (EC), and novel therapies based on the molecular profiling of EC cells are required. Materials and Methods: We used microarray analysis of EC tumour samples in order to identify tumour-specific changes regarding gene expression. Results: It was found that gremlin 2, an inhibitor of bone morphogenetic protein (BMP) signaling, was repressed in EC samples, and that gremlin 2 inhibited tumour cell growth. Conclusion: Down-regulation of gremlin 2 may lead to carcinogenesis and progression of EC. We suggest that re-activation of gremlin 2-associated pathways could suppress EC progression and should thus be explored as a potential novel therapeutic approach. ER -