RT Journal Article SR Electronic T1 Gremlin 2 is Repressed in Invasive Endometrial Cancer and Inhibits Cell Growth In Vitro JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 199 OP 203 VO 36 IS 1 A1 HIROSHI TSUBAMOTO A1 KAZUKO SAKATA A1 RIYA SAKANE A1 KAYO INOUE A1 HIROAKI SHIBAHARA A1 HIROYUKI HAO A1 SEIICHI HIROTA YR 2016 UL http://ar.iiarjournals.org/content/36/1/199.abstract AB Background: There exist limited therapeutic opportunities regarding the treatment of endometrial cancer (EC), and novel therapies based on the molecular profiling of EC cells are required. Materials and Methods: We used microarray analysis of EC tumour samples in order to identify tumour-specific changes regarding gene expression. Results: It was found that gremlin 2, an inhibitor of bone morphogenetic protein (BMP) signaling, was repressed in EC samples, and that gremlin 2 inhibited tumour cell growth. Conclusion: Down-regulation of gremlin 2 may lead to carcinogenesis and progression of EC. We suggest that re-activation of gremlin 2-associated pathways could suppress EC progression and should thus be explored as a potential novel therapeutic approach.