PT - JOURNAL ARTICLE AU - HIROSHI TSUBAMOTO AU - KAZUKO SAKATA AU - RIYA SAKANE AU - KAYO INOUE AU - HIROAKI SHIBAHARA AU - HIROYUKI HAO AU - SEIICHI HIROTA TI - Gremlin 2 is Repressed in Invasive Endometrial Cancer and Inhibits Cell Growth <em>In Vitro</em> DP - 2016 Jan 01 TA - Anticancer Research PG - 199--203 VI - 36 IP - 1 4099 - http://ar.iiarjournals.org/content/36/1/199.short 4100 - http://ar.iiarjournals.org/content/36/1/199.full SO - Anticancer Res2016 Jan 01; 36 AB - Background: There exist limited therapeutic opportunities regarding the treatment of endometrial cancer (EC), and novel therapies based on the molecular profiling of EC cells are required. Materials and Methods: We used microarray analysis of EC tumour samples in order to identify tumour-specific changes regarding gene expression. Results: It was found that gremlin 2, an inhibitor of bone morphogenetic protein (BMP) signaling, was repressed in EC samples, and that gremlin 2 inhibited tumour cell growth. Conclusion: Down-regulation of gremlin 2 may lead to carcinogenesis and progression of EC. We suggest that re-activation of gremlin 2-associated pathways could suppress EC progression and should thus be explored as a potential novel therapeutic approach.