RT Journal Article
SR Electronic
T1 Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 409
OP 413
VO 36
IS 1
A1 DIRK RADES
A1 ANTONIO J. CONDE-MORENO
A1 JON CACICEDO
A1 BARBARA SZEGEDIN
A1 STEVEN E. SCHILD
YR 2016
UL http://ar.iiarjournals.org/content/36/1/409.abstract
AB Aim: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma. Patients and Methods: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates. Results: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001). Conclusion: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.