TY - JOUR T1 - Clinicopathological Features of Surgically-resected Biliary Tract Cancer Following Chemo-radiation Therapy JF - Anticancer Research JO - Anticancer Res SP - 335 LP - 342 VL - 36 IS - 1 AU - SHOGO KOBAYASHI AU - KUNIHITO GOTOH AU - HIDENORI TAKAHASHI AU - HIROFUMI AKITA AU - SHIGERU MARUBASHI AU - TERUMASA YAMADA AU - TERUKI TESHIMA AU - KINJI NISHIYAMA AU - MASAHIKO YANO AU - HIROAKI OHIGASHI AU - OSAMU ISHIKAWA AU - MASATO SAKON Y1 - 2016/01/01 UR - http://ar.iiarjournals.org/content/36/1/335.abstract N2 - Aim: We retrospectively investigated surgery following chemo-radiation in patients with biliary tract cancer (BTC) treated at our Institution. Patients and Methods: Among 339 patients, 44 patients underwent chemo-radiation prior to surgery. Chemo-radiation entailed 2-3 months of standardized chemotherapy and 50-60 Gy radiation at the main tumor and regional and para-aortic lymph nodes. Results: Thirty-one BTC cases were classified as initially resectable (IR) and 13 as initially un-resectable (UR). Eighty percent of the BTCs were diagnosed as extrahepatic bile duct cancers. Gemcitabine (1,000 mg/m2) and radiation was used to treat 59% of patients. Thirty percent of patients underwent hemi-hepatectomy, and 50% underwent pancreatoduodenectomy. The R0 resection rate was 90% among IR and 54% among UR, and 3-year survival rates were 82% for IR and 17% for UR, respectively. Conclusion: This retrospective analysis suggests that surgery after chemoradiation may contribute to R0 resection rate and survival for initially resectable BTC. ER -