RT Journal Article
SR Electronic
T1 Clinicopathological Features of Surgically-resected Biliary Tract Cancer Following Chemo-radiation Therapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 335
OP 342
VO 36
IS 1
A1 KOBAYASHI, SHOGO
A1 GOTOH, KUNIHITO
A1 TAKAHASHI, HIDENORI
A1 AKITA, HIROFUMI
A1 MARUBASHI, SHIGERU
A1 YAMADA, TERUMASA
A1 TESHIMA, TERUKI
A1 NISHIYAMA, KINJI
A1 YANO, MASAHIKO
A1 OHIGASHI, HIROAKI
A1 ISHIKAWA, OSAMU
A1 SAKON, MASATO
YR 2016
UL http://ar.iiarjournals.org/content/36/1/335.abstract
AB Aim: We retrospectively investigated surgery following chemo-radiation in patients with biliary tract cancer (BTC) treated at our Institution. Patients and Methods: Among 339 patients, 44 patients underwent chemo-radiation prior to surgery. Chemo-radiation entailed 2-3 months of standardized chemotherapy and 50-60 Gy radiation at the main tumor and regional and para-aortic lymph nodes. Results: Thirty-one BTC cases were classified as initially resectable (IR) and 13 as initially un-resectable (UR). Eighty percent of the BTCs were diagnosed as extrahepatic bile duct cancers. Gemcitabine (1,000 mg/m2) and radiation was used to treat 59% of patients. Thirty percent of patients underwent hemi-hepatectomy, and 50% underwent pancreatoduodenectomy. The R0 resection rate was 90% among IR and 54% among UR, and 3-year survival rates were 82% for IR and 17% for UR, respectively. Conclusion: This retrospective analysis suggests that surgery after chemoradiation may contribute to R0 resection rate and survival for initially resectable BTC.