TY - JOUR T1 - Once Daily Accelerated Partial Breast Irradiation: Preliminary Results with Helical Tomotherapy® JF - Anticancer Research JO - Anticancer Res SP - 3035 LP - 3039 VL - 36 IS - 6 AU - UGO DE PAULA AU - ROLANDO M. D'ANGELILLO AU - RAFFAELE BARBARA AU - CRISTINA CARUSO AU - SARA GOMELLINI AU - AURELIA CACCAVARI AU - LEOPOLDO COSTARELLI AU - PAOLA SCAVINA AU - MARIA MAURI AU - ELENA SANTINI AU - ADRIANA ANTONACI AU - FRANCESCO CAVALIERE AU - MASSIMO LA PINTA AU - ANDREA LORETI AU - LUCIO FORTUNATO Y1 - 2016/06/01 UR - http://ar.iiarjournals.org/content/36/6/3035.abstract N2 - Background: Accelerated partial breast irradiation (APBI) is becoming an option for patients with low-risk breast cancer. The current practice is 38.5 Gy in 10 fractions b.i.d. over 5 days. This fractionation has a higher bioequivalent dose compared to the standard schedule. We report on preliminary results of once-daily APBI in patients treated with TomoTherapy®. Patients and Methods: Patients with unifocal-breast disease who underwent breast-conserving surgery were enrolled in the study. Treatment was administered with TomoTherapy, by contouring in accordance with the NSABP B-39/RTOG 0413 APBI protocol. Treatment schedule was 38.5 Gy in 10 once-daily fractions. EORTC Cosmetic Rating System was adopted for cosmetic outcome. Results: From 2010 to 2013, 111 patients were treated. With a median follow-up of 34 months, no ipsilateral breast recurrence was observed. Very few patients (1-4%) assessed their cosmetic outcome as fair or poor during follow-up. Conclusion: Once-daily APBI with TomoTherapy yielded good cosmetic results without compromising local control efficacy. ER -