RT Journal Article
SR Electronic
T1 Once Daily Accelerated Partial Breast Irradiation: Preliminary Results with Helical Tomotherapy®
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3035
OP 3039
VO 36
IS 6
A1 UGO DE PAULA
A1 ROLANDO M. D'ANGELILLO
A1 RAFFAELE BARBARA
A1 CRISTINA CARUSO
A1 SARA GOMELLINI
A1 AURELIA CACCAVARI
A1 LEOPOLDO COSTARELLI
A1 PAOLA SCAVINA
A1 MARIA MAURI
A1 ELENA SANTINI
A1 ADRIANA ANTONACI
A1 FRANCESCO CAVALIERE
A1 MASSIMO LA PINTA
A1 ANDREA LORETI
A1 LUCIO FORTUNATO
YR 2016
UL http://ar.iiarjournals.org/content/36/6/3035.abstract
AB Background: Accelerated partial breast irradiation (APBI) is becoming an option for patients with low-risk breast cancer. The current practice is 38.5 Gy in 10 fractions b.i.d. over 5 days. This fractionation has a higher bioequivalent dose compared to the standard schedule. We report on preliminary results of once-daily APBI in patients treated with TomoTherapy®. Patients and Methods: Patients with unifocal-breast disease who underwent breast-conserving surgery were enrolled in the study. Treatment was administered with TomoTherapy, by contouring in accordance with the NSABP B-39/RTOG 0413 APBI protocol. Treatment schedule was 38.5 Gy in 10 once-daily fractions. EORTC Cosmetic Rating System was adopted for cosmetic outcome. Results: From 2010 to 2013, 111 patients were treated. With a median follow-up of 34 months, no ipsilateral breast recurrence was observed. Very few patients (1-4%) assessed their cosmetic outcome as fair or poor during follow-up. Conclusion: Once-daily APBI with TomoTherapy yielded good cosmetic results without compromising local control efficacy.