TY - JOUR T1 - Changes in Pulmonary Function After Stereotactic Body Radiotherapy and After Surgery for Stage I and II Non-small Cell Lung Cancer, a Description of Two Cohorts JF - Anticancer Research JO - Anticancer Res SP - 6773 LP - 6779 VL - 35 IS - 12 AU - LEONIE ALBERTS AU - SHERIF Y. EL SHAROUNI AU - FREDERIK N. HOFMAN AU - BART P. VAN PUTTE AU - ELLEN TROMP AU - MARCO VAN VULPEN AU - ELISABETH A. KASTELIJN AU - FRANZ M.N.H. SCHRAMEL Y1 - 2015/12/01 UR - http://ar.iiarjournals.org/content/35/12/6773.abstract N2 - Aim: To evaluate changes in pulmonary function tests (PFTs) at different follow-up durations after stereotactic body radiotherapy (SBRT) and surgery in stage I and II non-small-cell lung cancer (NSCLC). Patients and Methods: Differences between pre-treatment- and follow-up PFTs were analyzed in 93 patients treated with surgery and 30 patients treated with SBRT for NSCLC. Follow-up durations were categorized into: early (0-9 months), middle (10-21 months) and late (≥22 months). Wilcoxon signed-rank test was used to analyze differences between pre-treatment and follow-up PFTs. Results: Forced expiratory volume in one second, forced vital capacity and diffusion capacity for carbon monoxide corrected for the actual hemoglobin level significantly diminished after surgery for all follow-up durations: 11-17% of predicted values. After SBRT, PFTs remained stable, but a declining trend of 6% (p=0.1) was observed after 22 months. Conclusion: SBRT might lead to less treatment-related toxicity measured by PFTs than surgery in both the short and long term. ER -