RT Journal Article
SR Electronic
T1 Systemic Inflammatory Response After Open, Laparoscopic and Robotic Surgery in Endometrial Cancer Patients
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2909
OP 2922
VO 36
IS 6
A1 RADOVAN PILKA
A1 RADIM MAREK
A1 TOMAS ADAM
A1 MILAN KUDELA
A1 DANA ONDROVÁ
A1 DAVID NEUBERT
A1 JOZEF HAMBÁLEK
A1 MARTIN MADĚRKA
A1 DAGMAR SOLICHOVÁ
A1 LENKA KUJOVSKÁ KRČMOVÁ
A1 BOHUSLAV MELICHAR
YR 2016
UL http://ar.iiarjournals.org/content/36/6/2909.abstract
AB Aim: To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. Materials and Methods: A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively. Results: The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups. Conclusion: The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma.