TY - JOUR T1 - Clinical Value of Squamous Cell Carcinoma Antigen (SCCAg) in Anal Cancer – A Single-Center Retrospective Analysis JF - Anticancer Research JO - Anticancer Res SP - 3173 LP - 3177 VL - 36 IS - 6 AU - CHRISTOPH HENKENBERENS AU - HAKAN TOKLU AU - CARSTEN TAMME AU - FRANK BRUNS Y1 - 2016/06/01 UR - http://ar.iiarjournals.org/content/36/6/3173.abstract N2 - Aim: To assess the clinical value of squamous cell carcinoma antigen (SCCAg) in anal cancer for chemoradiotherapy (CRT) patients. Patients and Methods: In 24 patients with SCC of the anus, SCCAg was determined before CRT and at every follow-up visit. Results: 16/24 (66.7%) had normal SCCAg and 11/16 (68.8%) achieved complete remission (CR), while 7/8 (87.5%) with elevated SCCAg achieved CR. In two patients, elevated SCCAg was observed after radiotherapy. One was false-positive and one was true-positive leading to diagnosis of metachronous recurrent and metastatic disease after interim CR. Conclusion: SCCAg was inappropriate to predict the clinical outcome but can provide additional information on the regular follow-up examinations to detect a relapse. ER -