PT  - JOURNAL ARTICLE
AU  - RATHMANN, NILS
AU  - BUDJAN, JOHANNES
AU  - MARI, FATINAH
AU  - GRIMM, ROBERT
AU  - ATTENBERGER, ULRIKE
AU  - KOSTRZEWA, MICHAEL
AU  - SADICK, MALIHA
AU  - SCHOENBERG, STEFAN O.
AU  - DIEHL, STEFFEN J.
TI  - Semiautomatic Whole-lesion Apparent Diffusion Coefficient Assessment for Early Prediction of Liver Tumor Response to Radioembolization
DP  - 2016 Jun 01
TA  - Anticancer Research
PG  - 2961--2966
VI  - 36
IP  - 6
4099  - http://ar.iiarjournals.org/content/36/6/2961.short
4100  - http://ar.iiarjournals.org/content/36/6/2961.full
SO  - Anticancer Res2016 Jun 01; 36
AB  - Aim: To evaluate volume-based apparent diffusion coefficient (ADCVOL) values for early prediction of therapy response after radioembolization (RE) of primary and secondary liver malignancies using a semiautomatic, image analysis software prototype. Patients and Methods: In a retrospective analysis, 74 target lesions were assessed in terms of therapy response 1 month after RE using magnetic resonance imaging. Changes of the diameter of the target lesions, the mean ADC value in a representative single-slice region of interest (ADCROI) and mean ADCVOL were correlated. Results: The median progression-free interval (PFI) of patients overall was 3.5±5.9 months. PFI in patients with an ADCVOL increase was statistically significantly longer than in patients with an ADCVOL decrease (mean PFI=6.5 vs. 2.5 months; p=0.0374). No correlation between PFI and early changes in lesion diameter or ADCROI was found. Conclusion: Semiautomatic, software-based ADC volume measurements seem to offer a clinically valuable parameter for early prediction of therapy response in patients after RE.