RT Journal Article SR Electronic T1 Wire-guided Localization in Non-palpable Breast Cancer: Results from Monocentric Experience JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2423 OP 2427 VO 36 IS 5 A1 STEFANO TARDIOLI A1 LAURA BALLESIO A1 SILVIA GIGLI A1 FRANCESCA DI PASTENA A1 VALERIO D'ORAZI A1 GUGLIELMO GIRALDI A1 MASSIMO MONTI A1 MARIA IDA AMABILE A1 VITTORIO PASTA YR 2016 UL http://ar.iiarjournals.org/content/36/5/2423.abstract AB Background: Breast-conserving surgery (BCS) is considered the gold-standard treatment for early breast cancer. Ultrasound-guided percutaneous biopsy or stereotactic biopsy of a breast lesion allows preoperative histological diagnosis. Various techniques have been proposed for identifying non-palpable breast tumors, but the most popular method is the wire-guided localization (WGL) technique. The aim of this study was to propose an alternative technique for optimizing the WGL procedure, facilitating breast surgery and reducing complications. Patients and Methods: We performed a prospective study on 40 patients with a single non-palpable breast lesion. For the preoperative localization of mammary lesions, patients were divided randomly into two groups: 20 patients underwent conventional WGL technique and 20 underwent ‘optimized’ personalized technique. Results: In the group treated with the optimized technique, dislocation of the wire occurred in only 2/20 cases, whereas in those with the conventional technique, dislocation occurred in 9/20 cases (p=0.03). In 5/20 cases of the conventional WGL technique, the wire was accidentally cut by the surgeon, whereas no similar complications were observed in the group that underwent the optimized technique (p=0.047). Re-excision of the surgical margins was necessary in 6/20 cases with the conventional technique, while re-excision was not required for any case using the optimized technique (p=0.02). Conclusion: The proposed optimized technique ensures good esthetic results, enabling the surgeon to identify the lesion and perform oncoplastic breast surgery, and allows surgical time to be reduced.