TY - JOUR T1 - Salvage High-dose-rate Interstitial Brachytherapy for Pelvic Recurrent Cervical Carcinoma After Hysterectomy JF - Anticancer Research JO - Anticancer Res SP - 2413 LP - 2421 VL - 36 IS - 5 AU - NAOYA MURAKAMI AU - TOMOYASU KATO AU - YUICHIRO MIYAMOTO AU - SATOSHI NAKAMURA AU - AKIHISA WAKITA AU - HIROYUKI OKAMOTO AU - KEISUKE TSUCHIDA AU - TAIRO KASHIHARA AU - KAZUMA KOBAYASHI AU - KEN HARADA AU - MAYUKA KITAGUCHI AU - SHUHEI SEKII AU - KANA TAKAHASHI AU - REI UMEZAWA AU - KOJI INABA AU - YOSHINORI ITO AU - HIROSHI IGAKI AU - JUN ITAMI Y1 - 2016/05/01 UR - http://ar.iiarjournals.org/content/36/5/2413.abstract N2 - Background: The aim of this study was to report the clinical results of salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) for patients with cervical cancer with pelvic recurrence after hysterectomy. Patients and Methods: When there was no indication for total pelvic extenteration (TPE) and the tumor depth was more than 5 mm of invasion in the paracolpium, salvage HDR-ISBT was applied. Results: A total of 26 patients were included in this study. The median number of fractions and dose per fraction of HDR-ISBT were 5 (range=3-20 fractions) and 6 Gy (range=2.5-6 Gy), respectively. Three-year local control, progression-free survival, and overall survival were 51.1%, 34.4% and 57.1%, respectively. Combination of external-beam radiation therapy, clinical target volume D90 greater than 65 Gy, and dose per fraction greater than 5 Gy were associated with favorable local control. Conclusion: For patients with recurrent cervical cancer post hysterectomy who are not candidates for TPE, salvage HDR-ISBT is a possible curative treatment modality. ER -