RT Journal Article
SR Electronic
T1 Impact of Recombinant Human Soluble Thrombomodulin for Disseminated Intravascular Coagulation
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2493
OP 2496
VO 36
IS 5
A1 SHINJI ITOH
A1 KEN SHIRABE
A1 SHUNJI KOHNOE
A1 NORIAKI SADANAGA
A1 KIYOSHI KAJIYAMA
A1 MOTOYUKI YAMAGATA
A1 HIDEAKI ANAI
A1 NORIFUMI HARIMOTO
A1 TORU IKEGAMI
A1 TOMOHARU YOSHIZUMI
A1 YOSHIHIKO MAEHARA
YR 2016
UL http://ar.iiarjournals.org/content/36/5/2493.abstract
AB Background: Early treatment of disseminated intravascular coagulation (DIC) can be associated with improved early outcomes. We aimed to evaluate the effectiveness of recombinant human soluble thrombomodulin (rTM) administration in patients with peritonitis-induced DIC. Patients and Methods: We treated 39 patients with DIC or pre-DIC caused by peritonitis at the Department of Surgery and Science, Kyushu University, and related facilities between January and December 2013. Results: Patients surviving to 28 days after DIC treatment had significantly better platelet counts, DIC scores, and sequential organ failure assessment scores at 7 days than did those who died earlier than 28 days. Patients receiving rTM had significantly better overall survival rates at 28 days and the results of multivariate analysis showed that rTM administration for DIC treatment was a prognostic indicator of 28-day survival in patients with peritonitis. Conclusion: rTM administration for the treatment of DIC or pre-DIC complicated by peritonitis had acceptable early outcomes.