TY - JOUR T1 - Prognostic Factors After Definitive Radio(Chemo)Therapy of Locally Advanced Head and Neck Cancer JF - Anticancer Research JO - Anticancer Res SP - 2523 LP - 2526 VL - 36 IS - 5 AU - DANIEL SEIDL AU - STEFAN JANSSEN AU - PRIMOZ STROJAN AU - AMIRA BAJROVIC AU - STEVEN E. SCHILD AU - DIRK RADES Y1 - 2016/05/01 UR - http://ar.iiarjournals.org/content/36/5/2523.abstract N2 - Aim: To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m2 of cisplatin weekly, three courses of cisplatin 100 mg/m2, two courses of cisplatin 5x20 mg/m2 or two courses of cisplatin 5×20 mg/m2plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose. Results: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m2 or 5×20 mg/m2 (p<0.001) were predictors of improved OS. Conclusion: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted. ER -