RT Journal Article
SR Electronic
T1 Risk Factors and Time to Occurrence of Genitourinary Toxicity After External Beam Radiotherapy for Prostate Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2441
OP 2444
VO 36
IS 5
A1 KANEMOTO, AYAE
A1 MATSUMOTO, YASUO
A1 SUGITA, TADASHI
A1 ABE, EISUKE
A1 YAMANA, NOBUKO
A1 SAITO, TOSHIHIRO
A1 KOBAYASHI, KAZUHIRO
A1 YAMAZAKI, HIROYUKI
A1 BILIM, VLADIMIR
A1 TANIKAWA, TOSHIKI
YR 2016
UL http://ar.iiarjournals.org/content/36/5/2441.abstract
AB Aim: To retrospectively investigate the risk factors and time to occurrence of genitourinary (GU) toxicity after radiotherapy for localized prostate cancer. Patients and Methods: The study included 320 patients. The radiotherapy planning target volume encompassed the prostate with a 1-cm margin in the transverse plane and a 1-cm margin (Group A) or a 1.5-cm margin (Group B) in the longitudinal plane. Incidence rates, risk factors and time to occurrence of GU toxicity were evaluated. Results: After a median follow-up of 38.2 months, the rate of late grade 2-3 GU toxicity was 5.9% and the median interval was 18.3 months. The wider longitudinal margin was the single significant independent factor. The 2-year cumulative incidence rates of late grade ≥2 GU toxicity were 2.8% and 7.5% in Group A and B patients. Conclusion: A wider radiotherapy margin increased the risk of GU toxicity and led to earlier occurrence.