PT  - JOURNAL ARTICLE
AU  - KANEMOTO, AYAE
AU  - MATSUMOTO, YASUO
AU  - SUGITA, TADASHI
AU  - ABE, EISUKE
AU  - YAMANA, NOBUKO
AU  - SAITO, TOSHIHIRO
AU  - KOBAYASHI, KAZUHIRO
AU  - YAMAZAKI, HIROYUKI
AU  - BILIM, VLADIMIR
AU  - TANIKAWA, TOSHIKI
TI  - Risk Factors and Time to Occurrence of Genitourinary Toxicity After External Beam Radiotherapy for Prostate Cancer
DP  - 2016 May 01
TA  - Anticancer Research
PG  - 2441--2444
VI  - 36
IP  - 5
4099  - http://ar.iiarjournals.org/content/36/5/2441.short
4100  - http://ar.iiarjournals.org/content/36/5/2441.full
SO  - Anticancer Res2016 May 01; 36
AB  - Aim: To retrospectively investigate the risk factors and time to occurrence of genitourinary (GU) toxicity after radiotherapy for localized prostate cancer. Patients and Methods: The study included 320 patients. The radiotherapy planning target volume encompassed the prostate with a 1-cm margin in the transverse plane and a 1-cm margin (Group A) or a 1.5-cm margin (Group B) in the longitudinal plane. Incidence rates, risk factors and time to occurrence of GU toxicity were evaluated. Results: After a median follow-up of 38.2 months, the rate of late grade 2-3 GU toxicity was 5.9% and the median interval was 18.3 months. The wider longitudinal margin was the single significant independent factor. The 2-year cumulative incidence rates of late grade ≥2 GU toxicity were 2.8% and 7.5% in Group A and B patients. Conclusion: A wider radiotherapy margin increased the risk of GU toxicity and led to earlier occurrence.