TY - JOUR T1 - Ifosfamide and Etoposide Chemotherapy in the Treatment of Recurrent/Refractory Rhabdomyosarcoma in Adults JF - Anticancer Research JO - Anticancer Res SP - 2429 LP - 2432 VL - 36 IS - 5 AU - SHINSUKE SASADA AU - MAKOTO KODAIRA AU - TATSUNORI SHIMOI AU - AKIHIKO SHIMOMURA AU - MAYU YUNOKAWA AU - KAN YONEMORI AU - CHIKAKO SHIMIZU AU - YASUHIRO FUJIWARA AU - KENJI TAMURA Y1 - 2016/05/01 UR - http://ar.iiarjournals.org/content/36/5/2429.abstract N2 - Background: No standard chemotherapy for adults with recurrent/refractory rhabdomyosarcoma (RMS) has yet been established. The present study aimed to assess the effect of ifosfamide and etoposide (IE) chemotherapy on previously treated RMS. Patients and Methods: Adults with recurrent/refractory RMS were treated with ifosfamide (1,800 g/m2/day), etoposide (100 mg/m2/day) and mesna (1,080 mg/m2/day) for 5 days. The effect and toxicity were evaluated by chart review. Results: Fifteen patients, with a median age of 33 years (range=25-67 years), were treated with IE chemotherapy. A median of six cycles of chemotherapy were administered and an objective response was obtained in eight patients. The median progression-free survival was 5.2 months (95% confidence interval=2.3-6.7 months) and overall survival was 14.4 months (95% confidence interval=4.6-28.3 months). Toxicity greater than grade 3 was as follows: neutropenia in all patients, anemia in seven, thrombocytopenia in seven and febrile neutropenia in eight. Conclusion: IE chemotherapy could be an alternative optional treatment method in adults with recurrent/refractory RMS. ER -