PT  - JOURNAL ARTICLE
AU  - LENA A. VON SCHUCKMANN
AU  - MATTHEW H. LAW
AU  - GRANT W. MONTGOMERY
AU  - ADELE C. GREEN
AU  - JOLIEKE C. VAN DER POLS
TI  - Vitamin D Pathway Gene Polymorphisms and Keratinocyte Cancers: A Nested Case-Control Study and Meta-Analysis
DP  - 2016 May 01
TA  - Anticancer Research
PG  - 2145--2152
VI  - 36
IP  - 5
4099  - http://ar.iiarjournals.org/content/36/5/2145.short
4100  - http://ar.iiarjournals.org/content/36/5/2145.full
SO  - Anticancer Res2016 May 01; 36
AB  - Background: The vitamin D endocrine system is implicated in skin carcinogenesis and polymorphisms in genes associated with the vitamin D receptor (VDR) gene may alter the risk of keratinocyte cancers (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)). Materials and Methods: In a nested case-control study of 1,124 adults, we investigated associations between polymorphisms in VDR-related pathways and incident keratinocyte cancers during 11 years of follow-up using adjusted multivariate regression analysis. We also performed a meta-analysis of rs2228570, rs7975232, rs1544410 and rs739837 polymorphisms. Results: A total of 286 BCCs and 161 SCCs were newly-diagnosed during follow-up. Participants with rs2228570 and rs927650 recessive genotypes had a decreased risk of SCC (odds ratio (OR)=0.34, 95% confidence interval (CI)=0.17-0.68; OR=0.48, CI=0.27-0.84, respectively). Meta-analysis showed a lower SCC risk in rs1544410 recessive genotypes (summary OR (SOR)=0.74, CI=0.53-0.94), while rs7975232 and rs739837 recessive genotypes were associated with a decreased BCC risk (SOR=0.74, CI=0.56-0.98; SOR=0.65, CI=0.43-0.88). Conclusion: Our meta-analysis indicated that vitamin D receptor polymorphisms may be associated with the risk of keratinocyte cancers.