TY - JOUR T1 - Symptomatic Radiation Pneumonitis After Accelerated Partial Breast Irradiation Using Three-dimensional Conformal Radiotherapy JF - Anticancer Research JO - Anticancer Res SP - 2475 LP - 2479 VL - 36 IS - 5 AU - NAOTO SHIKAMA AU - YU KUMAZAKI AU - KAZUNARI MIYAZAWA AU - KAZUNORI MIYAURA AU - SHINGO KATO AU - NAOKI NAKAMURA AU - JIRO KAWAMORI AU - TAKUYA SHIMIZUGUCHI AU - NAOKO SAITO AU - TOSHIAKI SAEKI Y1 - 2016/05/01 UR - http://ar.iiarjournals.org/content/36/5/2475.abstract N2 - Aim: To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT). Patients and Methods: The prescribed radiation dose was 30 Gy in 5 fractions over 10 days. Toxicity was graded according to the Common Terminology Criteria for Adverse Events (version 4.0). Results: Fifty-five patients were enrolled from August 2010 to October 2013 and the median follow-up time was 30 months (range=18-46 months). Three patients (5%) developed grade 2 symptomatic radiation pneumonitis after 3D-CRT APBI. Among 16 patients with ILV10Gy (% ipsilateral lung receiving ≥10 Gy) of 10% or higher, three patients (19%) developed symptomatic radiation pneumonitis. This trend was not observed in any of the patients with ILV10Gy less than 10% (p=0.005). Conclusion: High ILV10Gy might be associated with symptomatic radiation pneumonitis after 3D-CRT APBI. ER -