PT  - JOURNAL ARTICLE
AU  - ANTONIETA ALVARADO
AU  - ANA I. FAUSTINO-ROCHA
AU  - RITA FERREIRA
AU  - RAFAEL MENDES
AU  - JOSÉ ALBERTO DUARTE
AU  - MARIA JOÃO PIRES
AU  - BRUNO COLAÇO
AU  - PAULA A. OLIVEIRA
TI  - Prognostic Factors in an Exercised Model of Chemically-induced Mammary Cancer
DP  - 2016 May 01
TA  - Anticancer Research
PG  - 2181--2188
VI  - 36
IP  - 5
4099  - http://ar.iiarjournals.org/content/36/5/2181.short
4100  - http://ar.iiarjournals.org/content/36/5/2181.full
SO  - Anticancer Res2016 May 01; 36
AB  - Background/Aim: Estrogen receptor α (ERα) and Ki-67 are strong prognostic and predictive markers in woman breast cancer. This study aimed to evaluate the immunoexpression of prognostic factor markers ERα, Ki-67 proliferation index (Ki-67 PI) and the mitotic activity index (MAI) in mammary tumors induced by 1-methyl-1-nitrosourea (MNU) in female Sprague-Dawley rats submitted to lifelong exercise training. Materials and Methods: Thirty female rats were injected with MNU and randomly divided into two groups: sedentary and exercised. Results: All neoplasms from both groups were ERα-positive with an H-score ≥20. Statistically significant differences were not found in the ERα H-score, Ki-67 PI and MAI between groups. The absolute value of ERα H-score was higher in the exercised group, while the Ki-67 PI and MAI were higher in the sedentary group. Conclusion: Tumors from the exercised group were less proliferative and more differentiated, suggesting that long-term exercise training had positive effects on mammary carcinogenesis.