PT  - JOURNAL ARTICLE
AU  - SOTARO SADAHIRO
AU  - TOSHIYUKI SUZUKI
AU  - AKIRA TANAKA
AU  - KAZUTAKE OKADA
AU  - GOTA SAITO
AU  - AKEMI KAMIJO
AU  - HIDEKI NAGASE
TI  - Increase in Gene Expression of <em>TYMP</em>, <em>DPYD</em> and <em>HIF1A</em> Are Associated with Response to Preoperative Chemoradiotherapy Including S-1 or UFT for Rectal Cancer
DP  - 2016 May 01
TA  - Anticancer Research
PG  - 2433--2440
VI  - 36
IP  - 5
4099  - http://ar.iiarjournals.org/content/36/5/2433.short
4100  - http://ar.iiarjournals.org/content/36/5/2433.full
SO  - Anticancer Res2016 May 01; 36
AB  - Aim: The aim of the study was to identify biomarkers capable of predicting response to preoperative chemoradiotherapy (CRT) including S-1 or UFT for rectal cancer using biopsy specimens obtained before CRT (Pre-samples) and 7 days after the start of CRT (Day-7 samples). Materials and Methods: Preoperative CRT including S-1 or UFT was performed in 82 patients with locally advanced rectal cancer. The expression levels of 18 genes related to 5-fluorouracil, folate, and radiation in the Pre-samples and the Day-7 samples were evaluated using reverse transcription polymerase chain reaction (RT-PCR) assay. Results: The gene expression levels of hypoxia inducible factor 1 alpha subunit (HIF1A), dihydropyrimidine dehydrogenase (DPYD) and thymidine phosphorylase (TYMP) were found significantly increased in Day-7 samples compared to Pre-samples in responders, but not in non-responders. Conclusion: Increases in gene expression levels of TYMP, DPYD, and HIF1A in tumor tissues at 7 days after the start of CRT may be useful for predicting the efficacy of CRT including S-1 or UFT.